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尉志武(YU, Zhi-Wu)
博士，教授，博导，副系主任
(Ph.D., Professor of Chemistry)
Tel. (0) 10-62792492
Fax. (0) 10-62771149
Email:yuzhw@tsinghua.edu.cn
学历教育及博士后经历情况:
学士学位（BSc）：清华大学化学与化学工程系(1984);
硕士学位（MSc）: 清华大学化学系（1987）;
博士学位（PhD）: 伦敦大学（英国）（King’s College London，1995）;
博士后（Postdoc）：伊利诺伊大学（美国）（香槟分校 UIUC, 1996-98）
主要学术与社会兼职:
中国化学会理事、 化学热力学与热分析专业委员会主任；
北京正负电子对撞机国家实验室同步实验室用户委员会委员。
课题组介绍：
生命是物质运动的最高形式，因此在生命科学领域耕耘既具有挑战性，又充满乐趣。本课题组的主要研究方向是采用各种现代物理化学手段去解决生命科学中的基本问题。目前的研究课题主要有：
分子识别。提出了一种新的、基于二维相关光谱技术的研究方法，研究多组分体系中分子间选择性相互作用及竞争性相互作用。将在方法学的建立与完善、小分子与生物大分子的相互作用研究、药物分子的筛选等方面开展工作。
生物膜相变与稳定性。磷脂是生物膜的主要成分之一，依靠自组织现象而形成的脂双层是生物膜的基本结构。在正常生理条件下，生物膜磷脂的相态多处于液晶态。然而，温度等各种条件的变化将会诱导膜结构由液晶态向其它相态转化。例如植物在自然环境中受寒、受旱时，其细胞膜相态结构就会变化。因此，研究生物膜相变的机理具有重大的理论及实际意义。本研究组的工作主要侧重生物膜模型膜相变机理、特殊聚集体（如 Rafts）的形成规律等方面的研究。
纳米尺度分子有序聚集体的构筑规律与疏水作用的本质。生物分子常常依靠自组织现象形成有序的高级结构，这些有序分子聚集体往往表现出单个分子所不具有的性质与功能。探讨分子聚集体内和分子聚集体之间的弱相互作用的本质、阐明分子间如何相互识别、寻找结合位点以及分子间如何通过协同效应组装形成稳定的有序高级结构既是分子以上层次化学研究的核心和基础，也是认识生命现象本质的关键。本研究组主要侧重研究磷脂、糖脂、凝集素等构成的高级有序结构以及疏水作用的本质。
代表性文章（Representative Publications）:
1 Characterisation of a quasi-crystalline Phase in Codispersions of Phosphatidylethanolamine and Glucocerebroside, Biophysical Journal, 86(4): 2208-2217 (2004). (Feng Y, Rainteau D, Chachaty C, Yu ZW*, Wolf C, and Quinn PJ)
2 The kinetics and mechanism of the formation of crystalline phase of dipalmitoylphosphatidylethanolamine dispersed in dimethyl sulfoxide solutions. Chemistry and Physics of Lipids, 127(2): 153-159 (2004)(Chen L, Xie X, Yu ZW*, Quinn PJ)
3 Selective molecular interactions between dimethyl sulfoxide and paraldehyde studied by two-dimensional correlation FT-IR spectroscopy. Vibrational Spectroscopy,36(2): 61-64 (2004) (Liu J, Feng Y, Chen L, Wu GS, Yu ZW*),
4 Phase behavior of dipalmitoylphosphatidylethanolamine in dimethylsulfoxide–water mixture. Thermochimica Acta,416(1-2): 35-38 (2004). (Chen L, Yu ZW*, Feng Y, Xie X, and Quinn PJ)
5 Stable cubic phase in the codispersion of glucocerebroside and palmitoyloleoylphosphatidylethanolamine, Chemistry and Physics of Lipids, 126(2): 141-148 (2003). （Feng Y, Yu ZW*, and Quinn PJ）
6 Effect of Noise on the Evaluation of Correlation Coefficients in Two-Dimensional Correlation Spectroscopy, Applied Spectroscopy,57(12): 1605-1609(2003). （Yu ZW*, J. Liu, and Noda I）
7 On the Normalization Method in 2D-Correlation Spectra when Concentration is used as Perturbation Parameter. Applied Spectroscopy 57(2)164-167 (2003) (Yu ZW* and Noda I)
8 Binding Reaction of Hemin with Chloroquine, Quinine, and Quinidine in Water-Propylene Glycol Mixture, Chinese Journal of Chemistry,21(8): 1022-1025(2003)(Mavakala BK, Nlandu BB, Mpiana PT, Gushimana ZY, Yu ZW*)
9 Determination of Selective Molecular Interactions Using Two Dimensional Correlation FTIR Spectroscopy, Journal of Physical Chemistry A 106(30): 6683-6687(2002)(Yu ZW*, Chen L, Sun SQ, and Noda I)
10 Characterisation of the liquid-expanded to liquid-condensed phase transition of monolayers by means of compressibility, Langmuir, 18(11): 4530-4531 (2002)(Yu ZW*, Jin J, and Cao Y)
11 二价金属离子对鲑鱼精DNA热稳定性的影响, 高等学校化学学报，23(12): 2366-2368 (2002) (邬瑞光, 尉志武*, 陈琳, 周蕊)
12 Effect of Urea, dimethylurea, and tetramethylurea on the phase behavior of dioleoylphosphatidylethanolamine, Chemistry and Physics of Lipids, 114(2): 149-157(2002)(Feng Y, Yu ZW*, and Quinn PJ)
13 Non-zero Solubility Rule. Tsinghua Science and Technology, 7(1): 15-16 (2002). (Yu ZW*, Zhou R, and Liu Y)
14 Crystallization behavior of DSPE in dimethyl sulphoxide by time-resolved infrared spectroscopy and differential scanning calorimetry. Journal of Macromolecular Science-Physics B 41(1):137-147 (2002). (Chen L, Yu ZW*)
15 Excess molar enthalpies for binary mixtures of benzylalcohol and heptanone isomers at different temperatures.Journal of Chemical Engineering Data, 46(5): 1258 - 1260 (2001) (Zhao X, Yu ZW*, Zhou R, and Liu Y)
16 Characterisation of the kinetic phase transition of phospholipids using Avrami and Tobin Models. Chinese Journal of Chemistry, 19(8): 719-723 (2001).(Chen L, Yu ZW*, Xue FY, and Hong XY)
17 A principle to correlate extreme values of excess thermodynamic functions with partial molar quantities. Science in China B, 44(3): 315-319 (2001). (Yu ZW*, Liu Y, Zhou R, and Xue FY)
18 Kinetic phase behavior of distearoylphosphatidylethanolamine dispersed in glycerol. Biophysical Chemistry 89(2-3): 229-236(2001). (Chen L, Yu ZW*, and Quinn PJ)
19 The effect of dimethyl sulphoxide on the structure and phase behaviour of palmitoleoylphosphatidylethanolamine Biochim. Biophys. Acta. 1509:440-40 (2000). (Yu ZW and Quinn PJ*)
20 Combination of differential scanning calorimetry and X-ray diffraction in the study of phase behaviours of lipids – a mini review. Journal of Thermal Analysis and Calorimetry58:201-207 (1999). (Yu ZW* and Liu Y)
21 Volumetric properties of binary systems between tetralin and alkylbenzenes. Fluid Phase Equilibria 164(2): 209-216 (1999). (Yu ZW*, He XH, Zhou R, and Liu Y)
22 Solvation effects of dimethyl sulphoxide on the structure of phospholipid bilayers. Biophysical Chemistry 70(1): 35-39(1998). (Yu ZW and Quinn PJ*)
23 The modulation of membrane structure and stability by dimethyl sulphoxide (review). Molecular Membrane Biology 15:59-68 (1998). (Yu ZW and Quinn PJ*)
24 Molecular forces between membranes displaying neutral glycosphingolipids: evidence for carbohydrate attraction. Biochemistry 37(6): 1540-1550 (1998). (Yu ZW, Calvet TL, and Leckband D*)
25 Thermotropic properties of dioleoylphosphatidylethanolamine in aqueous dimethylsulphoxide solutions. Archives of Biochemistry and Biophysics332(1): 187-195 (1996). (Yu ZW, Williams WP, and Quinn PJ*)
26 Phase stability of phosphatidylcholines in dimethylsulphoxide solutions. Biophysical Journal69(4): 1456-1463(1995). (Yu ZW and Quinn PJ*)
27 Phase behaviour of distearoylphosphatidylethanolamine in glycerol - A thermal and X-ray diffraction study. Biochim. Biophys. Acta.1237(2): 135-142 (1995). (Yu ZW,TsvetkovaNM, Tsonev LI, and Quinn PJ*)
28 Dimethyl sulphoxide: a review of its applications in cell biology. Bioscience Reports 14(6): 259-281(1994).(Yu ZW and Quinn PJ*) |
