基本情况

胡跃飞 (1957)

清华大学化学系，北京 100084

yfh@mail.tsinghua.edu.cn

电话：010-62795380

工作经历

2002- 清华大学化学系教授，博士生导师。

1996-2002 南京大学化学系教授，博士生导师。

1991-1996 美国华盛顿大学医学院 (St. Louis) 分子生物学和分子药理学系工作，Research Associate，D. F. Covey 教授课题组。

1987-1988 南京大学化学系讲师。

1983-1984 北京理工大学助教。

受教育经历

1988-1990 博士后；美国南佛罗里达大学《分子设计和识别中心》，G. R. Newkome 教授课题组。

1984-1987 理学博士；南京大学化学系。

1980-1983 理学硕士；南京大学化学系。

1977-1980 大学毕业；南京大学化学系。

研究方向和兴趣

生物有机化学 具有生物活性的复杂和天然化合物的设计、合成和性质研究

杂环化学 具有生物活性杂环化合物的合成和方法研究

不对称合成 手性化合物的合成和方法研究

药物化学 国家级新药的研制

荣誉和奖励

1998年 教育部“跨世纪人才培养计划基金”获得者。

2000年 国家基金委“国家杰出青年基金” 获得者。

2000年 中国化学会首届“有机合成杰出青年奖” 获得者。

专业协会

美国化学会会员 (1992-)

中国化学会会员 (1997-)

专业兼职

中国化学会《化学学报》编委会委员 (1999-)

中国化学会《化学化学生物学专业委员会》委员 (2001-)

已经发表的部分论文

1. Cunde Wang, Xin Jiang, Haijian Shi, Jun Lu, Yuefei Hu* and Hongwen Hu, Optimization of the abnormal Beckmann rearrangement: Application to steroid 17-oximes. J. Org. Chem., 2003, 68, 4579-4581.

2. Shaozhong Wang, Gang Yu, Jun Lu, Kun Xiao, Yuefei Hu* and Hongwen Hu, A novel and regioselective tandem reaction between 2-acetamidoacetamide and chalcones promoted by Cs2CO3 for the preparation of 3-unsubstituted 4,6- diarylpyrid-2-ones. Synthesis 2003, 487-490.

3. Jun Lu, Xuenong Xu, Shaozhong Wang, Cunde Wang, Yuefei Hu* and Hongwen Hu, Novel preparation of non-racemic 1-[a-(1-azacycloalkyl)benzyl]-2-naphthols from Betti base and their application as chiral ligands in the asymmetric addition of diethylzinc to aryl aldehydes, J. Chem. Soc., Perkin Trans 1., 2002, 2900-2903.

4. Jun Lu, Xuenong Xu, Cunde Wang, Jiangang He, Yuefei Hu* and Hongwen Hu, Synthesis of chiral ligands derived from the Betti base and their use in the enantioselective addition of diethylzinc to aromatic aldehydes, Tetrahedron Lett., 2002, 43, 8367-8369.

5. Jie Wang, Xin Jiang, Ming Chen, Zongming Ge, Yuefei Hu* and Hongwen Hu, TFA catalyzed ring transformation of 4-hydroxycyclobutenone: TFA catalyzed ring transformation of 4-hydroxycyclobutenone: A facile and general route for preparation of 3-substituted 4-amino-2(5H)-furanones. J. Chem. Soc., Perkin Trans 1., 2001, 66-71.

6. Xin Jiang, Jie Wang, Jiaxin Hu, Zongming Ge, Yuefei Hu* and Hongwen Hu, Synthesis of (5a)-17-azaandrostan-3-ols and (5a)-17-aza-D-homoandrostan-3-ols and their N-acylated derivatives. Steroids 2001, 66, 655-662.

7. Jie Wang, Xin Jiang, Ming Chen, Yuefei Hu* and Hongwen Hu, A novel coupling reaction of cyclobutene-1,2-diones induced by low-valent titanium. J. Organomet. Chem., 2001, 629, 213-218.

8. Jiaxin Hu, Xin Jiang, Ting He, Jan Zhou, Yuefei Hu* and Hongwen Hu, Novel synthetic routes for nitrogen-bridged tricyclic derivatives of pyrrolo[2,1,5-cd] indolizine and pyrrolo[2,1,5-de]quinolizine derived from 2-acyl-N-(acylmethyl- ene)pyridinium halides. J. Chem. Soc., Perkin Trans 1., 2001, 1820-1825.

9. Feng Liang, Jiaxin Hu, Lande Zhang, Yuefei Hu* and Hongwen Hu, Preparation of pyrrolo[2,1,5-cd]indolizine derivatives by intramolecular condensation of 3-acyl-5-methylindolizines. J. Heterocyclic Chem., 2001, 38, 853-857.

10. Xin Jiang, Cunde Wang, Yuefei Hu* and Hongwen Hu, A practical and facile route for the preparation of 18-norandrostan-17-ones from androstan-17-ones using SmI2 promoted cyclization and dehydroxylation. J. Org. Chem., 2000, 65, 3555-3557.

11. D.F. Covey,* M. Han, A.S. Kumar, M.A.M. de la Cruz, E.S. Meadows, Yuefei Hu, A. Tonnies, D. Nathan, M. Coleman, A. Benz, A.S. Evers, C.F. Zorumski, S. Mennerick, Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3a,5a)- and (3a,5b)-3-hydroxypregnan-20-one. J. Med. Chem., 2000, 43, 3201-3204.

12. Lande Zhang, Feng Liang, Lingzhi Sun, Yuefei Hu* and Hongwen Hu, A novel synthesis of 3-unsubstituted indolizines. Synthesis 2000, 1733-1737.

13. Jian Zhou, Yuefei Hu* and Hongwen Hu, Synthesis of pyrrolo[2,1-a]phthalazines by 1,3-dipolar cycloaddition of phthalazinium N-ylides with alkenes in the presence of tetrakis-pyridine cobalt (II) dichromate. J. Heterocyclic Chem., 2000, 37, 1165-1168.

14. Bingxiang Wang, Jiaxin Hu, Xuechun Zhang, Yuefei Hu* and Hongwen Hu, Oxidant promoted 1,3-dipolar cycloaddition of benzimidazolium ylides to alkenes for preparation of 4H-pyrrolo[1,2-a]benzimidazole. J. Heterocyclic Chem., 2000, 37, 1533-1537.

15. Bingxiang Wang, Xuechun Zhang, Jun Li, Xin Jiang, Yuefei Hu* and Hongwen Hu, Preparation of 3-indolizincarboxamides and 3-indolizinecarbonitriles by 1,3-cycloaddition of N-cyanomethylpyridinium ylides with alkenes in the presence of TPCD or MnO2. J. Chem. Soc., Perkin Trans I, 1999, 1571-1575.

16. Jian Zhou, Yuefei Hu,* Hongwen Hu, The first approach to the synthesis of indolizines by intramolecular 1,5-dipolar cyclization of 2-(2-arylethenyl)pyridium ylides in the presence of tetrakis-pyridine cobalt (II) dichromate. Synthesis 1999, 166-170.

17. Yuefei Hu, L.L. Wittmer, M. Kalkbrenner, A.S. Evers, C.F. Zorumski, D.F. Covey,* Neurosteroid analogues 5. Enantiomers of neuroactive steroids and benz[e]indenes: total synthesis, electrophysiological effects on GABAA receptor function and anesthetic action in tadpoles. J. Chem. Soc., Perkin Trans I, 1997, 3665-3671.

18. Yuefei Hu, K.A. Yamada, D.K. Chalmers, D.P. Annavajjula, D.F. Covey,* Enantioselectivity synthesis of cyclothiazide analogues: Novel probes of the stereospecific actions of benzothiadizines at AMPA-type glutamate receptors. J. Am. Chem. Soc., 1996, 118, 4550-4559.

19. L.L. Wittmer, Yuefei Hu, M. Kalkbrenner, A.S. Evers, C.F. Zorumski, D.F. Covey,* Enantioselectivity of steroid-induced GABAA receptor modulation and anesthesia. Molecular Pharmacology 1996, 50, 1581-1586.

20. Yuefei Hu, C.F. Zorumski, D.F. Covey,* Neurosteroid analogues. 2. Total synthesis and electrophysiological evaluation of a benz[e]indene analogue of the anesthetic steroid alphaxalone. J. Org. Chem., 1995, 60, 3619-2635.

21. Yuefei Hu, P.C. Sherwin, D.F. Covey,* Synthesis of (17R)- and (17S)-hydroxy-14,15-secoandrost-4-en-15-yn-3-one and the X-ray structure of the (17S)-diastereomer. Steroids, 1995, 60, 491-496.

22. M. Han, Yuefei Hu, C.F. Zorumski, D.F. Covey,* Neurosteroid analogues. 3. Synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5b-cofiguation. J. Med. Chem., 1995, 38, 4548-4556.

23. Yuefei Hu,* Xudong Wei, Hongwen Hu, Tetrakis-pyridino-cobalt (II) dichromate Py4Co(HCrO4)2 (TPCD). in Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A., Paquette, John Wiley & Sons, New York, 1995, Vol. 7, 4780-4781.

24. B.P. Schlegel, J.E. Pawlowski, Yuefei Hu, D.M. Scolnick, D.F. Covey, T.M. Penning,* Steroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3a-hydroxysteroid dehydrogenase. Biochemistry, 1994, 33, 10367-10374.

25. Yuefei Hu, D.F. Covey,* Synthesis of 1,10-seco-5a-estr-1-ynes: Potential mechanism-based inhibitors of 3a- and 3b-hydroxysteroid dehydrogenases. J. Chem. Soc., Perkin Trans. I, 1993, 417-422.

26. Xudong Wei, Yuefei Hu,* Tingshen Li, Hongwen Hu, A facile one-step synthesis of aromatic indollizines by 1,3-dipolar cycloaddition of pyridinium and related heteroaromatic ylides with alkenes in the presence of TPCD [Py4Co(HCrO4)2]. J. Chem. Soc., Perkin Trans. I, 1993, 2487-2489.

27. Yuefei Hu, C.F. Zorumski, D.F. Covey,* Structure-activity studies of ben[e]indenes modulation of GABA reception function. 1. The effect of 6-methyl substituted on electrophisiology activity. J. Med. Chem., 1993, 36, 3956-3967.

28. D.F. Covey,* Yuefei Hu, M.G. Bouly, K.D. Holland, N.T. Rodgers-Neame, K.E. Isenberg, C.F. Zorumski, Modulation of GABA receptor function by benz[e]indenes and phenanthrenes. J. Med. Chem., 1993, 36, 627-630.

已申请和批准的专利

29. 胡跃飞，许学农，李 锐，董艳梅，陆 军，胡宏纹，1-(a-氨基苄基)-2-萘酚的缩酮 (醛) 化合物及其制法和用途，中国发明专利，申请号: 02157261.5，受理日期：2002.12.26。

30. 胡跃飞，陆军，许学农，王少仲，胡宏纹，手性化合物 S-(+)- 和 R-(-)- 1-(a-氨基苄基)-2-萘酚的制备方法，中国发明专利，申请号：01129170.1，受理日期：2001.09.04。公开日期：2002.05.15。

31. D.F. Covey, Yuefei Hu, C.F. Zorumski. Novel Tricyclic Steroid Analogs. European Patent. Patent No. 0548824. Patent data: Jan. 31, 1996.

32. D.F. Covey, Yuefei Hu, M. Han, C.F. Zorumski, Benz[e]indene Compounds. United States Patent, Patent No. 5,434,274. Patent data: July 18, 1995. Int. Cl. C07D 317/72. U.S.Cl. 549/336.

33. D.F. Covey, Yuefei Hu, C.F. Zorumski, Tricyclic Steroid Analogs. United States Patent, Patent No. 5,292,906. Patent data: March 08, 1994. Int. Cl. C07C 69/74. U.S.Cl. 552/619.

34. D.F. Covey, Yuefei Hu, C.F. Zorumski, Tricyclic Steroid Analogs. United States Patent, Patent No. 5,344,826. Patent data: Sept. 06, 1994. Int. Cl. A01N 45/00. U.S.Cl. 514/167.

35. D.F. Covey, Yuefei Hu, C.F. Zorumski. Tricyclic Steroid Analogs. United States Patent, Patent No. 5,206,415. Patent data: April 27, 1993. Int. Cl. C07C 69/608. U.S.Cl. 560/117.